{"id":185,"date":"2015-03-31T12:33:20","date_gmt":"2015-03-31T10:33:20","guid":{"rendered":"http:\/\/new.veterinasmizany.sk\/?page_id=185"},"modified":"2015-05-22T13:33:37","modified_gmt":"2015-05-22T11:33:37","slug":"mdr1","status":"publish","type":"page","link":"https:\/\/www.chsseychely.sk\/?page_id=185","title":{"rendered":"MDR1"},"content":{"rendered":"<p><strong>MDR1<\/strong><\/p>\n<p>Austr\u00e1lske ov\u010diaky, spolu s\u00a0niektor\u00fdmi k\u00f3liovit\u00fdmi plemenami m\u00f4\u017eu pren\u00e1\u0161a\u0165 genetick\u00fa mut\u00e1ciu, ktor\u00e1 ich rob\u00ed citliv\u00fdmi na niektor\u00e9 lieky. Pou\u017eitie t\u00fdchto liekov m\u00f4\u017ee sp\u00f4sobi\u0165 v\u00e1\u017ene neurologick\u00e9 pr\u00edznaky a\u00a0a\u017e smr\u0165.<\/p>\n<p>Na\u0161\u0165astie je u\u017e dnes genetick\u00fd test, ktor\u00fd v\u00e1m povie, \u010di v\u00e1\u0161 pes m\u00e1 t\u00fato mut\u00e1ciu.\u00a0 Jedin\u00e9 \u010do potrebujete je urobi\u0165 l\u00edcny ster. Nie je nevyhnutn\u00e9 \u00eds\u0165 ku veterin\u00e1rovi.<\/p>\n<p><strong>Ak\u00fd presn\u00fd je test?<\/strong><\/p>\n<p>Extr\u00e9mne. Identifikuje v\u00e1m genotyp testovan\u00e9ho psa: presnej\u0161ie, ktor\u00fa formu MDR1 g\u00e9nu pes m\u00e1.<\/p>\n<p><strong>\u010co je MDR1?<\/strong><\/p>\n<p>MDR1 je skr\u00e1ten\u00fd n\u00e1zov pre g\u00e9n naz\u00fdvan\u00fd multi liekov\u00e1 rezistencia 1 ( Multi drug resistance 1). Mut\u00e1cia tohto g\u00e9nu sp\u00f4sobuje citlivos\u0165 na Ivermekt\u00edn a\u00a0nieko\u013eko \u010fal\u0161\u00edch liekov. Psi s\u00a0mut\u00e1ciou bud\u00fa reagova\u0165 na podanie t\u00fdchto liekov. Intenzita reakcie z\u00e1vis\u00ed od d\u00e1vky lieku. Psi nemusia reagova\u0165 na n\u00edzke d\u00e1vky lieku, ako s\u00fa napr. pou\u017eit\u00e9 v\u00a0pr\u00edpravkoch proti srdcov\u00fdm \u010dervom. Typick\u00e9 d\u00e1vky a\u00a0a\u00a0r\u00f4znorodos\u0165 liekov sp\u00f4sobia reakciu u\u00a0psov s\u00a0dvoma k\u00f3piami mut\u00e1cie, ale niektor\u00e9 lieky \u2013 naj\u010dastej\u0161ie niektor\u00e9 chemoterapeutik\u00e1 \u2013m\u00f4\u017eu sp\u00f4sobi\u0165 reakciu aj u\u00a0psov s\u00a0jednou k\u00f3piou mut\u00e1cie.<\/p>\n<p>Psi s\u00a0mut\u00e1ciou maj\u00fa \u201echybu\u201c transportu lieku \u2013 liek prejde do mozgu a nevie by\u0165 transportovan\u00fd von, preto doch\u00e1dza k\u00a0toxick\u00fdm hladin\u00e1m v\u00a0mozgu. Toto sp\u00f4sobuje v\u00e1\u017ene neurologick\u00e9 pr\u00edznaky, z\u00e1chvaty a\u00a0niekedy aj smr\u0165.<\/p>\n<p><strong>Ktor\u00e9 lieky sp\u00f4sobuj\u00fa MDR1 reakciu?<\/strong><\/p>\n<p>Ivermekt\u00edn, je prv\u00fd liek rozpoznan\u00fd ako ten, ktor\u00fd sp\u00f4sobuje reakciu, ale je ich viac. Ivermekt\u00edn v\u00a0n\u00edzkych d\u00e1vkach ako sa pou\u017e\u00edva v\u00a0liekoch proti srdcov\u00fdm \u010dervom nesp\u00f4sob\u00ed reakciu. Vy\u0161\u0161ie d\u00e1vky potrebn\u00e9 napr. na od\u010dervenie sp\u00f4sobia. Ostatn\u00e9, be\u017ene pou\u017e\u00edvan\u00e9 lieky na zozname zah\u0155\u0148aj\u00fac acepromaz\u00edn a\u00a0Imodium. Na\u0161\u0165astie je dnes mo\u017enos\u0165 alternat\u00edvnej lie\u010dby ak ju v\u00e1\u0161 pes potrebuje.<\/p>\n<p>Lieky na zozname, m\u00f4\u017eete n\u00e1js\u0165 aj na VCPL webstr\u00e1nke.<\/p>\n<p>Psi, ktor\u00ed s\u00fa MDR1 \u201eclear\u201c m\u00f4\u017eu pou\u017e\u00edva\u0165 lieky na zozname. (zoznam priklad\u00e1m na konci \u010dl\u00e1nku, pozn. Prekladate\u013ea)<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Ktor\u00e9 plemen\u00e1 s\u00fa postihnut\u00e9?<\/strong><\/p>\n<ul>\n<li>Austr\u00e1lsky ov\u010diak ( 50%)<\/li>\n<li>Border k\u00f3lia ( menej ako 5%)<\/li>\n<li>K\u00f3lie (dlhosrst\u00e1 a\u00a0kr\u00e1tkosrst\u00e1) \u00e470%)<\/li>\n<li>Anglick\u00fd ov\u010diak (15%)<\/li>\n<li>Nemeck\u00fd ov\u010diak ( 10%)<\/li>\n<li>Dlhosrst\u00fd vipet (65%)<\/li>\n<li>Miniat\u00farny austr\u00e1lsky ov\u010diak (50%)<\/li>\n<li>Kr\u00ed\u017eence (5%)<\/li>\n<li>Staroanglick\u00fd ov\u010diak (5%)<\/li>\n<li>\u0160eltie (15%)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Ak\u00e1 \u010dast\u00e1 je mut\u00e1cia u\u00a0AUO?<\/strong><\/p>\n<p>Jeden z\u00a0dvoch AUO m\u00e1 aspo\u0148 jednu k\u00f3piu MDR1 mut\u00e1cie.<\/p>\n<p><strong>Ako viem, \u017ee aj m\u00f4j AUO m\u00e1 mut\u00e1ciu?<\/strong><\/p>\n<p>Ak v\u00e1\u0161 pes u\u017e mal reakciu na niektor\u00e9 z\u00a0liekov v\u00a0zozname, tak m\u00e1 mut\u00e1ciu. Bohu\u017eia\u013e reakcia m\u00f4\u017ee by\u0165 tak\u00e1 nebezpe\u010dn\u00e1, \u017ee je dobr\u00e9 otestova\u0165 psa sk\u00f4r ako mu bude podan\u00fd ak\u00fdko\u013evek liek zo zoznamu.<\/p>\n<p><strong>\u010co znamen\u00e1\u00a0 MDR1 genetick\u00fd test?<\/strong><\/p>\n<p>Je to test DNA mut\u00e1cie. Poukazuje na to, \u010di pes m\u00e1, alebo nem\u00e1 mut\u00e1ciu, a\u00a0ak ju m\u00e1, tak \u010di m\u00e1 jednu alebo dve k\u00f3pie.\u00a0 V\u00fdsledok v\u00e1m d\u00e1 genotyp psa,\u00a0 vo forme: Normal\/Normal, Normal\/Mutant alebo Mutant\/ Mutant. Pes aj s\u00a0jednou k\u00f3piou mut\u00e1cie m\u00f4\u017ee by\u0165 precitliven\u00fd na lieky v\u00a0zozname.<\/p>\n<p><strong>Mal by som poveda\u0165 veterin\u00e1rovi o\u00a0v\u00fdsledku testu?<\/strong><\/p>\n<p>\u00c1NO!!! Ak v\u00e1\u0161 pes m\u00e1 mut\u00e1ciu, zadov\u00e1\u017ete si k\u00f3piu v\u00fdsledku a\u00a0zoznamu liekov\u00a0 dajte to svojmu veterin\u00e1rovi, aby vedel, \u017ee tieto lieky u\u00a0V\u00e1\u0161ho psa nem\u00f4\u017ee pou\u017ei\u0165. Ak aj nech\u00e1te psa niekomu na starosti, ubezpe\u010dte sa, \u017ee mu d\u00e1vate aj k\u00f3piu v\u00fdsledku a\u00a0zoznamu liekov, pre pr\u00edpad, \u017ee by bolo nevyhnutn\u00e9 vyh\u013eada\u0165 veterin\u00e1ra po\u010das tejto starostlivosti. Je vhodn\u00e9 aj na obojok psa umiestni\u0165 \u0161t\u00edtok s\u00a0n\u00e1pisom informuj\u00facim o\u00a0precitlivenosti na lieky.<\/p>\n<p><strong>\u010cO znamen\u00e1 MDR1 \u201ecarrier\u201c ?<\/strong><\/p>\n<p>Psi aj s\u00a0jednou k\u00f3piou mut\u00e1cie s\u00fa postihnut\u00ed!!! Aj ke\u010f v\u00a0men\u0161ej miere, ale bud\u00fa neadekv\u00e1tne reagova\u0165 na ka\u017ed\u00fd z\u00a0liekov v\u00a0zozname, ak bude d\u00e1vka dostato\u010dne vysok\u00e1.<\/p>\n<p><strong>Ktor\u00fdch psov testova\u0165 a\u00a0ako \u010dasto?<\/strong><\/p>\n<p>Od kedy je dostupn\u00fd genetick\u00fd test, sta\u010d\u00ed psa otestova\u0165 iba raz.\u00a0 Vzh\u013eadom na vysok\u00fa frekvenciu mut\u00e1cie u\u00a0AUO a\u00a0mno\u017estvo liekov, na ktor\u00e9 m\u00f4\u017eu psi s\u00a0mut\u00e1ciou reagova\u0165, by mali by\u0165 v\u0161etci AUO, vr\u00e1tane t\u00fdch z\u00a0\u00fatulkov a po nezn\u00e1mych rodi\u010doch a\u00a0kr\u00ed\u017eence AUO otestovan\u00e9. Ich \u017eivoty m\u00f4\u017eu by\u0165 z\u00e1visl\u00e9 na tom.<\/p>\n<p>Jedin\u00e1 v\u00fdnimka je: Ak s\u00fa obaja rodi\u010dia otestovan\u00fd ako Normal\/ Normal, t\u00ed nem\u00f4\u017eu d\u00e1va\u0165 g\u00e9n \u010falej na potomstvo, tak\u017ee potomstvo nemus\u00ed by\u0165 otestovan\u00e9. Ale ak je pes s\u00a0v\u00fdsledok Normal\/Normal kr\u00ed\u017een\u00ed so psom neotestovan\u00fdm, alebo so psom, ktor\u00fd m\u00e1 jednu k\u00f3piu mut\u00e1cie, potomstvo mus\u00ed by\u0165 otestovan\u00e9.<\/p>\n<p><strong>\u010co\u00a0znamenaj\u00fa MDR1 pozit\u00edvne psi pre chovate\u013esk\u00fd program?<\/strong><\/p>\n<p>M\u00f4\u017eu sa kr\u00ed\u017ei\u0165 psi s\u00a0jednou alebo s\u00a0dvoma mut\u00e1ciami MDR1. MDR1 psi reaguj\u00fa na ur\u010dit\u00e9 lieky. Predt\u00fdm ako sa lieky dostali na veterin\u00e1rny trh, nikto sa neob\u00e1val tejto mut\u00e1cie, napriek tomu, \u017ee exituje u\u017e viac ako 1,5 storo\u010dia. Lieky na zozname, pou\u017e\u00edvan\u00e9 veterin\u00e1rmi, nie s\u00fa s\u00fa\u010das\u0165ou pr\u00edrody a\u00a0d\u00e1 sa predch\u00e1dza\u0165 ich pou\u017eitiu ak viete status svojho psa. Chovatelia ber\u00fa oh\u013ead na to, \u017ee mut\u00e1cia je chyba, ale nie diskvalifikuj\u00faca.\u00a0 Psi s\u00a0mut\u00e1ciou by ale mali by\u0165 kr\u00ed\u017een\u00ed len so psami \u201eclear\u201c.\u00a0 Jedince \u201eclear\u201c, by mali by\u0165 uprednost\u0148ovan\u00e9 na chov oproti t\u00fdm s\u00a0jednou alebo dvoma mut\u00e1ciami.\u00a0 Ak by sa to dodr\u017eiavalo, frekvencia mut\u00e1cie by sa \u010dasom zredukovala nato\u013eko, \u017ee by\u00a0 sa minimalizovalo riziko reakci\u00ed u\u00a0neotestovan\u00fdch psov.<\/p>\n<p>Testujte v\u0161etk\u00fdch chovn\u00fdch psov, pre odpor\u00fa\u010danie uveden\u00e9 vy\u0161\u0161ie. Mali by ste zv\u00e1\u017ei\u0165 otestovanie v\u0161etk\u00fdch \u0161teniat\u00a0 z\u00a0vrhu, kde m\u00e1 aspo\u0148 jeden rodi\u010d mut\u00e1ciu, sk\u00f4r ako p\u00f4jdu do nov\u00fdch domovov. V\u00a0krajnom pr\u00edpade,\u00a0 zabezpe\u010dte k\u00f3pie v\u00fdsledok testu od rodi\u010dov pre nov\u00fdch majite\u013eov a odporu\u010dte im aby si \u0161te\u0148at\u00e1 dali otestova\u0165.\u00a0 Nov\u00fd majitelia by mali by\u0165 pou\u010den\u00ed, \u017ee k\u00f3pie v\u00fdsledkov testu rodi\u010dov maj\u00fa da\u0165 aj svojim veterin\u00e1rom, aby do\u0161lo k\u00a0adekv\u00e1tnemu lie\u010deniu \u0161teniat, bez liekov na zozname. Ak bude \u0161te\u0148a vyu\u017e\u00edvan\u00e9 v\u00a0chove, presved\u010dte nov\u00e9ho majite\u013ea, \u017ee vy\u0161etrenie na MDR1 vy\u0161etrenie, je rovnako d\u00f4le\u017eit\u00e9 ako vy\u0161etrenie bedrov\u00fdch k\u013abov a\u00a0o\u010dn\u00e9 vy\u0161etrenie, predt\u00fdm ako bude pes pou\u017eit\u00fd v\u00a0chove.<\/p>\n<p>Ako \u010das ubieha a\u00a0\u010doraz viac psov je otestovan\u00fdch, je mo\u017en\u00e9 ur\u010di\u0165 aj na z\u00e1klade anal\u00fdzy rodokme\u0148ov\u00a0 predkov v\u00fdsledok dan\u00e9ho psa. Ak n\u00e1jdete len Normal\/Normal jedincov u\u00a0predkov, nie je nutn\u00e9 psa testova\u0165. Ale ak je \u010do i\u00a0len jeden neotestovan\u00fd, alebo m\u00e1 aspo\u0148 jednu k\u00f3piu mut\u00e1cie, je nutn\u00e9 psa otestova\u0165.<\/p>\n<p>Od kedy MDR1 sp\u00f4sobuje neurologick\u00e9 poruchy a\u00a0ob\u010das aj smr\u0165, nie je lep\u0161ie nepou\u017e\u00edva\u0165 v\u00a0chove MDR1 pozit\u00edvne jedince?<\/p>\n<p>ASHGI nedoporu\u010duje vyra\u010fova\u0165 z\u00a0chovu jedince s\u00a0MDR1mut\u00e1ciou!! T\u00e1to mut\u00e1cia je probl\u00e9m len preto, \u017ee sme zaviedli na trh lieky, ktor\u00e9 im sp\u00f4sobuj\u00fa ne\u017eiaduce reakcie.\u00a0 Ak by psi boli div\u00fd, nikdy by sa nedostali k\u00a0tak\u00fdm liekom. Podstata je, vedie\u0165 status svojho psa a\u00a0zabr\u00e1ni\u0165 pou\u017eitiu t\u00fdchto liekov u\u00a0psov s\u00a0mut\u00e1ciou.<\/p>\n<p>Polovica chovn\u00fdch pren\u00e1\u0161a\u010dov, m\u00e1 aspo\u0148 jednu k\u00f3piu mut\u00e1cie. Elimin\u00e1cia t\u00fdchto jedincov, by mohla nato\u013eko z\u00fa\u017ei\u0165 chovate\u013esk\u00fa z\u00e1klad\u0148u, \u017ee by sa mohli objavi\u0165 v\u00e1\u017enej\u0161ie ochorenia, na ktor\u00e9 nem\u00e1me mo\u017enos\u0165 testova\u0165. Chovatelia, by sa mali riadi\u0165 vy\u0161\u0161ie uveden\u00fdmi odpor\u00fa\u010daniami. Po \u010dase a\u00a0\u010fal\u0161\u00edch gener\u00e1ci\u00e1ch, frekvencia MDR1 mut\u00e1cie \u00a0sa zn\u00ed\u017ei, bez zni\u010denia genetickej z\u00e1kladne.<\/p>\n<p><strong>Sp\u00f4sobuje MDR1 mut\u00e1cia epilepsiu?<\/strong><\/p>\n<p>MDR1 reakcia nie je forma epilepsie, napriek tomu je prirovn\u00e1van\u00e1 k\u00a0epilepsii. MDR1 mut\u00e1cia je jednou z\u00a0mnoh\u00fdch vec\u00ed, ktor\u00e9 m\u00f4\u017eu sp\u00f4sobi\u0165 epileptiformn\u00e9\u00a0 ( podobn\u00e9 epilepsii, pozn. prekladate\u013ea) z\u00e1chvaty. Reakcia na lieky je ve\u013emi rozdielna oproti prim\u00e1rnej epilepsii.\u00a0 Pes bude ma\u0165 z\u00e1chvat, iba ak s\u00fa mu podan\u00e9 lieky zo zoznamu, ktor\u00e9 sa nahromadia v\u00a0mozgu.\u00a0 Lie\u010dba je in\u00e1, progn\u00f3za je in\u00e1 a\u00a0k\u0155\u010de samotn\u00e9 s\u00fa in\u00e9.\u00a0 MDR1 k\u0155\u010de s\u00fa len vtedy ak je vn\u00edmav\u00e9mu psovi podan\u00fd liek zo zoznamu.\u00a0 Ke\u010f d\u00f4jde k\u00a0\u00fapln\u00e9mu odb\u00faraniu lieku z mozgu, k\u0155\u010de prestan\u00fa.\u00a0 Ak pes nedostane \u017eiaden z\u00a0liekov na zozname,\u00a0 nikdy nebude ma\u0165 k\u0155\u010de.<\/p>\n<p>Od kedy je frekvencia MDR1 mut\u00e1cie tak\u00e1 vysok\u00e1 a\u00a0aj frekvencia epilepsie je vysok\u00e1, je mo\u017en\u00e9, \u017ee aj pes s\u00a0epilepsiou m\u00f4\u017ee ma\u0165 MDR1 mut\u00e1ciu. Tak\u00fd pes, potom bude ma\u0165 dva ochorenia, nie jedno. Je mo\u017en\u00e9, \u017ee ak pes trp\u00ed z\u00e1chvatmi z\u00a0lieku kv\u00f4li MDR1, epiz\u00f3da z\u00e1chvatov sa m\u00f4\u017ee zhor\u0161i\u0165 a\u00a0prejs\u0165 do epileptick\u00e9ho z\u00e1chvatu,\u00a0 ak trp\u00ed aj epilepsiou. Z\u00e1chvaty u\u00a0epileptick\u00e9ho psa nemaj\u00fa s\u00favislos\u0165 s\u00a0liekmi, t.j. vznikaj\u00fa bez oh\u013eadu na to, \u010di liek dostane alebo nie.<\/p>\n<p><strong>M\u00f4\u017ee po\u017eieranie v\u00fdkalov sp\u00f4sobi\u0165 MDR1 reakciu?<\/strong><\/p>\n<p>Ak pes s\u00a0MDR1 mut\u00e1ciou zo\u017eerie v\u00fdkaly od\u00a0 kon\u00ed, alebo dobytka, ktor\u00e9mu bol podan\u00fd Ivermekt\u00edn na lie\u010dbu parazitov, m\u00f4\u017ee ma\u0165 z\u00e1chvat. T\u00e1to reakcia m\u00f4\u017ee by\u0165 smrte\u013en\u00e1. Nie je jasn\u00e9 ako dlho Ivermekt\u00edn alebo ostatn\u00e9 lieky perzistuj\u00fa vo v\u00fdkaloch po exkr\u00e9cii.\u00a0 Napriek tomu, boli pop\u00edsan\u00e9\u00a0 reakcie psov po po\u017erat\u00ed trusu od kon\u00ed alebo oviec o\u0161etren\u00fdch Ivermekt\u00ednom. Ak neviete status svojho psa, mali by ste ho da\u0165 otestova\u0165.<\/p>\n<p><strong>Ak je m\u00f4j pes MDR1 pozit\u00edvny, je bezpe\u010dn\u00e9 mu da\u0165 o\u010disti\u0165 zubn\u00fd kame\u0148? <\/strong><\/p>\n<p>\u00c1no, ale ubezpe\u010dte sa, \u017ee v\u00e1\u0161 veterin\u00e1r nepou\u017eije na anest\u00e9ziu lieky zo zoznamu.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<table width=\"810\">\n<tbody>\n<tr>\n<td><strong>Lieky, ktor\u00e9 by sa nemali pou\u017e\u00edva\u0165 pri MDR1 pozit\u00edvnych jedincoch<\/strong><\/td>\n<\/tr>\n<tr>\n<td>\n<table>\n<tbody>\n<tr>\n<td width=\"157\"><strong>Acepromazine<\/strong><\/td>\n<td width=\"155\"><strong>Ivermectin<\/strong><\/td>\n<td width=\"154\"><strong>Loperamide<\/strong><\/td>\n<td width=\"155\"><strong>Milbemycin<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Ace<\/td>\n<td width=\"155\">Abamectin<\/td>\n<td width=\"154\">Acanol<\/td>\n<td width=\"155\">Inteceptor<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Acepro<\/td>\n<td width=\"155\">Acarexx<\/td>\n<td width=\"154\">Acqta<\/td>\n<td width=\"155\">Sentinel<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Aceproject<\/td>\n<td width=\"155\">Advantage DUO<\/td>\n<td width=\"154\">Anti-Diarrheal Formula<\/td>\n<td width=\"155\"><strong>Moxidectin<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Acevet<\/td>\n<td width=\"155\">Avermectin<\/td>\n<td width=\"154\">Cryoperacid<\/td>\n<td width=\"155\">Guardian Moxidectin<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">ACP<\/td>\n<td width=\"155\">Bimectin<\/td>\n<td width=\"154\">Deroser<\/td>\n<td width=\"155\">Proheart<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Atravet<\/td>\n<td width=\"155\">BMD\/Ivomec<\/td>\n<td width=\"154\">Diahalt<\/td>\n<td width=\"155\"><strong>Ribampin<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"157\">PromAce<\/td>\n<td width=\"155\">Ecomectin<\/td>\n<td width=\"154\">Diamode<\/td>\n<td width=\"155\">Ricilin<\/td>\n<\/tr>\n<tr>\n<td width=\"157\"><strong>Butorphanol<\/strong><\/td>\n<td width=\"155\">Equell<\/td>\n<td width=\"154\">Diarr-Eze<\/td>\n<td width=\"155\">Rifaldin<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Dolorex<\/td>\n<td width=\"155\">Equimax<\/td>\n<td width=\"154\">Diarrhea Relief<\/td>\n<td width=\"155\">Rifamp<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Stadol<\/td>\n<td width=\"155\">Equimectrin<\/td>\n<td width=\"154\">Hurplex<\/td>\n<td width=\"155\"><strong>Selamectin<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Torbugesic<\/td>\n<td width=\"155\">Eqvalan<\/td>\n<td width=\"154\">Imodium<\/td>\n<td width=\"155\">Revolution Topical<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Torbutrol<\/td>\n<td width=\"155\">Heartgard<\/td>\n<td width=\"154\">Imogen<\/td>\n<td width=\"155\">Stronghold<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Torphajet<\/td>\n<td width=\"155\">Ivercare<\/td>\n<td width=\"154\">Imotil<\/td>\n<td width=\"155\"><strong>Vinblastine<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"157\"><strong>Doxorubicin<\/strong><\/td>\n<td width=\"155\">Ivercide<\/td>\n<td width=\"154\">Imperim<\/td>\n<td width=\"155\">Lemblastine<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Adriamycin<\/td>\n<td width=\"155\">Iverhart<\/td>\n<td width=\"154\">Kao-Paverin Caps<\/td>\n<td width=\"155\">Solbalstin<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Adriblastina<\/td>\n<td width=\"155\">Iver-On<\/td>\n<td width=\"154\">Lop<\/td>\n<td width=\"155\">Velban<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Caelyx<\/td>\n<td width=\"155\">Iversol<\/td>\n<td width=\"154\">Loperacap<\/td>\n<td width=\"155\">Velbe<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Doxil<\/td>\n<td width=\"155\">Ivexterm<\/td>\n<td width=\"154\">Nodiamex<\/td>\n<td width=\"155\">Vincrex<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Doxolem<\/td>\n<td width=\"155\">Ivomec<\/td>\n<td width=\"154\">Permidal<\/td>\n<td width=\"155\">Vintec<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Doxotec<\/td>\n<td width=\"155\">Mectizan<\/td>\n<td width=\"154\">Pramidal<\/td>\n<td width=\"155\"><strong>Vincristine<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Hydroxydaunomycin<\/td>\n<td width=\"155\">Megamectin<\/td>\n<td width=\"154\">Raxamida<\/td>\n<td width=\"155\">Citomid<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Hydroxydoxorubicin<\/td>\n<td width=\"155\">Noromectin<\/td>\n<td width=\"154\">Rediarin<\/td>\n<td width=\"155\">Leurocristine<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Hydroxyldaunorubicin<\/td>\n<td width=\"155\">Panomec<\/td>\n<td width=\"154\">Top-Dal<\/td>\n<td width=\"155\">Oncovin<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Myocet<\/td>\n<td width=\"155\">Phoenectin<\/td>\n<td width=\"154\">Valfam<\/td>\n<td width=\"155\">Vinblax<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Rubex<\/td>\n<td width=\"155\">Primectin<\/td>\n<td width=\"154\"><strong><u>\u00a0<\/u><\/strong><\/td>\n<td width=\"155\">Vincasar<\/td>\n<\/tr>\n<tr>\n<td width=\"157\"><strong>Erythromycin<\/strong><\/td>\n<td width=\"155\">Privermectin<\/td>\n<td width=\"154\"><strong><u>\u00a0<\/u><\/strong><\/td>\n<td width=\"155\">Vincrex<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Abboticne<\/td>\n<td width=\"155\">SparMectin<\/td>\n<td width=\"154\"><strong><u>\u00a0<\/u><\/strong><\/td>\n<td width=\"155\">Vintec<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Aknin<\/td>\n<td width=\"155\">Stromectol<\/td>\n<td width=\"154\"><strong><u>\u00a0<\/u><\/strong><\/td>\n<td width=\"155\">&nbsp;<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Aipimycin<\/td>\n<td width=\"155\">Tri-Heart<\/td>\n<td width=\"154\"><strong><u>\u00a0<\/u><\/strong><\/td>\n<td width=\"155\">&nbsp;<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Erythrocin<\/td>\n<td width=\"155\">Unimectrin<\/td>\n<td width=\"154\">&nbsp;<\/td>\n<td width=\"155\">&nbsp;<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">Iliocin<\/td>\n<td width=\"155\">Virbamec<\/td>\n<td width=\"154\">&nbsp;<\/td>\n<td width=\"155\">&nbsp;<\/td>\n<\/tr>\n<tr>\n<td width=\"157\">&nbsp;<\/td>\n<td width=\"155\">Zimecterin<\/td>\n<td width=\"154\">&nbsp;<\/td>\n<td width=\"155\">&nbsp;<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Zdroj: <a href=\"http:\/\/www.ashgi.org\">www.ashgi.org<\/a><\/p>\n<p>Preklad: MVDr. Krist\u00edna Kova\u013eov\u00e1<\/p>\n","protected":false},"excerpt":{"rendered":"<p>MDR1 Austr\u00e1lske ov\u010diaky, spolu s\u00a0niektor\u00fdmi k\u00f3liovit\u00fdmi plemenami m\u00f4\u017eu pren\u00e1\u0161a\u0165 genetick\u00fa mut\u00e1ciu, ktor\u00e1 ich rob\u00ed citliv\u00fdmi na niektor\u00e9 lieky. Pou\u017eitie t\u00fdchto liekov m\u00f4\u017ee sp\u00f4sobi\u0165 v\u00e1\u017ene neurologick\u00e9 pr\u00edznaky a\u00a0a\u017e smr\u0165. Na\u0161\u0165astie je u\u017e dnes genetick\u00fd test, ktor\u00fd v\u00e1m povie, \u010di v\u00e1\u0161 pes&#8230;<a href=\"https:\/\/www.chsseychely.sk\/?page_id=185\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-185","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.chsseychely.sk\/index.php?rest_route=\/wp\/v2\/pages\/185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.chsseychely.sk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.chsseychely.sk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.chsseychely.sk\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.chsseychely.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=185"}],"version-history":[{"count":3,"href":"https:\/\/www.chsseychely.sk\/index.php?rest_route=\/wp\/v2\/pages\/185\/revisions"}],"predecessor-version":[{"id":281,"href":"https:\/\/www.chsseychely.sk\/index.php?rest_route=\/wp\/v2\/pages\/185\/revisions\/281"}],"wp:attachment":[{"href":"https:\/\/www.chsseychely.sk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}